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Currently Recruiting Studies

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Age-Related Macular Degeneration (AMD)

Geographic Atrophy

PROXIMA A

Natural History Geographic Atrophy Study
The primary objective of the study is to generate a better understanding of the variability and dynamic range of visual function tests over time and how these changes correlate with changes in Geographic Atrophy area in patients with Geographic Atrophy (GA) secondary to Aged related Macular Degeneration (AMD). The study includes 10 visits over 48 months (4 years) with one approximately 2-hour appointment every 6 months.

Principal Investigator: Professor Robyn Guymer
Study Coordinator: Emily Caruso
More information: PROXIMA A at ClinicalTrials.gov

To speak to a study coordinator, call 9929 8113 or email: emily.caruso@unimelb.edu.au

PROXIMA B

Natural History Geographic Atrophy Study
The primary objective of the study is to generate a better understanding of the variability and dynamic range of visual function tests over time and how these changes correlate with changes in Geographic Atrophy area in patients with Geographic Atrophy (GA) secondary to Aged related Macular Degeneration (AMD). The study includes 12 visits over 68 months (5 years) with one approximately 2-hour appointment every 6 months.

Principal Investigator: Professor Robyn Guymer
Study Coordinator: Emily Caruso
More information: PROXIMA b at ClinicalTrials.gov

To speak to a study coordinator, call 9929 8113 or email: emily.caruso@unimelb.edu.au

Diabetic Macular Oedema

LADAMO

A Phase IV randomised clinical trial of laser therapy for peripheral retinal ischaemia combined with intravitreal aflibercept (Eylea®) versus intravitreal aflibercept monotherapy for diabetic macular oedema

This is a 24-month phase IV, randomised, prospective, multicentre, clinical trial of laser therapy to areas of peripheral retinal ischaemia combined with intravitreal aflibercept versus intravitreal aflibercept monotherapy. Both arms will have 2mg intravitreal aflibercept according to a treat and extend protocol.

The specific aim of the study is to test whether laser therapy of peripheral retinal ischaemia reduces the overall number of intravitreal aflibercept injections required to control DMO over a 24-month period.

Principal Investigator: Dr Sanj Wickremasinghe
Study Coordinator: Sutha Sanmugasundram
More information: LADAMO at ClinicalTrials.gov.

To speak to a study coordinator, call 9929 8076, or email: cera-trials@unimelb.edu.au

Macular Telangiectasia

A Natural History Study of Macular Telangiectasia Type 2.

The Natural History and Registry Study (NHOR) is a world-wide registry of persons with Macular Telangiectasia (MacTel) Type II. Patients are enrolled at an initial visit with a comprehensive eye exam and imaging, and are contacted annually to update contact information. Any persons in the Registry will be informed of new findings about MacTel and clinical trial information.

Principal Investigator: Professor Robyn Guymer
Study Coordinator: Melinda Cain

To speak to a study coordinator, call 9929 8388, or email: mcain@unimelb.edu.au

Uveitis

POINT

Periocular and intravitreal corticosteroids for uveitis macular edema (POINT) trial

This is a six-month study to evaluate the relative efficacy of three commonly utilised regional corticosteroids for the regional treatment of uveitic macular edema: periocular triamcinolone acetonide; intravitreal triamcinolone acetonide; intravitreal dexamethasone implant. The primary efficacy measure will be percent change in central subfield thickness as measured by OCT at 8 weeks.

Principal Investigator: Dr Richard Stawell
Study Coordinator: Thuy Chau
More information: POINT at clinicaltrials.gov.

To speak to a study coordinator, call 9929 8076, or email: cera-trials@unimelb.edu.au

FAST

First-Line Antimetabolites as Steroid-sparing Treatment (FAST) Uveitis Trial

In the First-line Antimetabolites as Steroid-sparing Treatment (FAST) Uveitis Trial, the investigators propose to establish which immunosuppressive therapy, methotrexate or mycophenolate mofetil, is more effective as a first-line, corticosteroid-sparing agent for the treatment of non-infectious uveitis in a randomized, masked, comparative effectiveness trial.

The primary outcome is treatment success assessed at the 6-month visit. If patients are a treatment success, they continue the medication for another 6 months. Patients who are a treatment failure can crossover to the other medication.

Principal Investigator: A/Prof Lyndell Lim
Study Coordinator: Tanya Pejnovic
More information: FAST at clinicaltrials.gov.

To speak to a study coordinator, call 9929 8076, or email: cera-trials@unimelb.edu.au


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