Corneal Research

Topical cyclosporin A for acute corneal graft rejection: a doublemasked randomised controlled study

To assess if Cyclosporin A 0.05% has a demonstrable effect when used in conjunction with topical steroids in the treatment of acute graft rejection. CsA 0.05% (Restasis) does not appear to have any beneficial effects in the treatment of graft rejection when intensive steroids are already being used.

A randomised, single centre study of the equivalence of two intraocular lenses (IOLs) used in cataract surgery

The main objective of this prospective randomised study is to assess the safety and efficacy of the two IOL’s (Alcon IOL and Tecsoft IOL) in human eyes for the treatment of cataracts.

A comparative clinical trial of alcohol delamination versus phototherapeutic keratectomy for the treatment of recurrent corneal erosions

This prospective study seeks to investigate the clinical efficacy of alcohol delamination versus phototherapeutic keratectomy (PTK) for the treatment of traumatic recurrent corneal erosions (RCEs).

A prospective, randomised, clinical trial of Descemet’s Stripping Automated Endothelial Keratoplasty (DSAEK)

Investigation aims to determine clinical efficacy and incidence of adverse events in patients who have a corneal transplant using the DSAEK technique. A comparison will be made to patients who have a penetrating keratoplasty (PK) corneal transplant.

Differences in early and late corneal graft rejections

The aim of the study is to retrospectively analyse all cases of corneal transplants performed at the Royal Victorian Eye and Ear Hospital since July 1991 to 2007, and those with episodes of corneal graft rejection. Postoperative events, like persistent epithelial defect, wound dehiscence, suture related complications, and others, would also be assessed in all the cases.

Determinants of informed consent. Why do patients enter a clinical trial?

This study seeks to understand why patients choose or decline to participate in clinical trials and what are the determinants of patient’s participation in a clinical trial are.

A prospective, randomised, clinical trial of corneal collagen crosslinking in keratoconus

The aim of the project is to evaluate the clinical usefulness and efficacy collegian cross-linking in people with progressive keratoconus and to confirm its safety profile. We are also investigating the effects of the treatment on corneal microstructure and keratocytes, thickness, curvature and the accuracy of tonometric measurements.