Glaucoma Research

Ageing and glaucoma

Using laboratory techniques, this study is investigating specific cellular changes associated with aging in order people to determine what makes aged nerve cells (retinal ganglion cells) more vulnerable to damage in glaucoma. By identifying these key mechanisms that render an aged optic nerve susceptible to injury, we seek to identify therapeutic targets to protect the optic nerve and prevent vision loss from glaucoma.

Mitochondria and glaucoma

This work is investigating the role of agerelated changes in mitochondria on the ability of the optic nerve to withstand injury such as that induced by elevated eye pressure. Mitochondria are cellular organelles that produce energy that is vital for a cell to function and repair itself from damage. Research has identified chemical mediators that protect mitochondria from aging and the effect of these on the response of the optic nerve to elevated eye pressure is being explored.

Dietary restriction and glaucoma

Calorie restriction by fasting has been shown to decrease the susceptibility of age related processes is shown to improve resistance of cultured neurons to damages. This study investigates the mechanisms of calorie restriction on the resistance of the optic nerve to glaucoma, and is using novel therapeutic polyphenol compounds that mimic the calorie restriction process.

Wound healing – Avastin effect on wound healing in vitro and in vivo

Post-operative scarring is a major threat to successful glaucoma surgery and this study is working to find the best methods for lowering intraocular pressure, by regulating post-operative scar formation. Using standard and novel laboratory techniques we are gaining an understanding of the cellular response to anti-scarring agents that are of potential benefit in the postglaucoma surgery clinic.

Development of glaucoma surgical devices

Glaucoma filtration surgery success depends on preventing excess scar tissue formation around the wound site. This project is investigating how bio-mechanical forces in healing wounds modify the wound healing process. This will provide key information for improving surgical techniques and designing new surgical devices that promise to improve the outcome of glaucoma surgery.