Student opportunities

Validation and characterisation of biomarkers in mitochondrial optic neuropathy

This research position is open to expressions of interest from Honours, MSc and PhD students.

Supervisor: Dr Isabel Lopez Sanchez
Email: [email protected]
Suitable for:  Honours, MSc, PhD
Starting date: Anytime


Leber hereditary optic neuropathy (LHON) is the most common mitochondrial disease and causes irreversible blindness primarily in young men. Using RNA sequencing we have identified potential protective and pathogenic biomarkers in this disease. This project aims to:

  1. Validate the biomarker potential of identified targets using clinical samples
  2. Characterise the function of identified markers in cells and in iPSC-derived retinal organoids
  3. Investigate the biological relevance of identified markers in other optic neuropathies


Techniques and tools: Cell culture, stem cell technology, biochemistry, CRISPR-Cas 9, proteomics, immunocytochemistry, mitochondrial-specialised techniques

To learn more or apply for this opportunity, please email Dr Isabel Lopez Sanchez at [email protected]


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