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Gene function in keratoconus

Research Unit: Ocular Genetics
Primary Supervisor: Associate Professor Paul Baird
Tel: +613 9929 8613 / Email: pnb@unimelb.edu.au

Keratoconus is an eye disease affecting the cornea at the front of the eye and usually occurs in teenage years. Its causes are unknown but both genetic and environmental factors are implicated. An immune component to this disease is likely and a number of genes have been associated with keratoconus. This project will assess the role of immune genes and immune background through genotyping and sequencing as well as through gene expression studies in donor eye tissue. You will undertake a range of molecular biology and genetic techniques including DNA and RNA extraction, genotyping, copy number analysis, RT-PCR, RNA Seq and bioinformatics analysis.

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