About
Dr Xavier Hadoux
Postdoctoral Research Fellow, Ophthalmic Neuroscience
Dr Xavier Hadoux is investigating how the interaction between light and retinal tissue can serve as clinical biomarkers, using novel technology such as hyperspectral imaging.
Dr Xavier Hadoux
Postdoctoral Research Fellow, Ophthalmic Neuroscience
BSc MSc Meng PhD
Dr Xavier Hadoux is Senior Postdoctoral research fellow at the Centre for eye Research Australia (CERA) and the co-founder and Chief Technical Officer (CTO) at Enlighten Imaging Pty Ltd.
Dr Hadoux completed his PhD in data science at Montpellier University (France) in 2014. He holds both a Master of Science and a Master of Engineering from Grande Ecole in Nancy, France.
Since 2015, he has applied his engineering, physics and data science knowledge to medical device development and the detection of novel biomarker for eye and brain diseases.
Dr Hadoux has published 19 papers and is first author of a paper reporting the first in-vivo retinal biomarker for Alzheimer’s disease. He is the lead inventor of a system and method for biomarker detection from retinal hyperspectral images.
Dr Hadoux is a co-recipient of competitive commercialisation grant funding for novel retinal hyperspectral camera development. He and the team are developing a novel low-cost hyperspectral imaging system for clinical translation together with a medical product manufacturing partner.
Dr Hadoux co-developed the cross-modality annotation tool (XMAS) for advanced annotation of retinal images simultaneously on multiple modalities to streamline development of AI training datasets in ophthalmology.
Key research questions
- Can the retina be used as a biomarker for Alzheimer disease detection and screening?
- Can retinal hyperspectral imaging provide new biomarkers of various eye disease?
- Determine whether hyperspectral imaging biomarker can be translated to the clinic?
- How a multi-modality approach in combination with deep learning algorithm can be used for advanced biomarker detection?
Current projects
Selected publications
My team
Key collaborators
Funding and support
Current projects
- Low cost hyperspectral camera prototyping from benchtop to clinic
- Cross-modality retinal image annotation software to enable AI data analytics
- Hyperspectral biomarker discovery for eye and brain diseases
Selected publications
Hadoux X, Hui F, Lim JK, Masters CL, Pébay A, Chevalier S, et al. Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease. Nature communications. 2019;10(1):1-12. DOI: 10.1038/s41467-019-12242-1
Tang J, Hui F, Hadoux X, Soares B, Jamieson M, Crowston JG. An optimised protocol for the portable electroretinogram device to probe changes in glaucoma. Investigative Ophthalmology & Visual Science. 2018;59(9):3028-.
Tang J, Hui F, Hadoux X, Sarossy M, van Wijngaarden P, Coote M, et al. A Comparison of the RETeval Sensor Strip and DTL Electrode for Recording the Photopic Negative Response. Translational vision science & technology. 2018;7(6):27-. doi: https://doi.org/10.1167/tvst.7.6.27
Tang J, Hui F, Coote M, Crowston JG, Hadoux X. Baseline detrending for the photopic negative response. Translational vision science & technology. 2018;7(5):9-.
Hui F, Tang J, Hadoux X, Crowston JG. The effect of inter-stimulus frequency on the photopic negative response in glaucoma and healthy eyes. Investigative Ophthalmology & Visual Science. 2018;59(9):4443-.
See more publications
My team
- Maxime Jannaud – Electronic and software engineer
- Dr Francis Labrecque – Postdoctoral Research Fellow
- Darvy Dang – Research Assistant
- Roshan Karri – Student, Advanced retinal image analytics using deep learning
- Yimin (Luke) Lu – Student, Hyperspectral biomarker characterisation in age related macular degeneration (AMD)
- Omar Salehi – Student, Hyperspectral characterisation of retinal naevi
Key collaborators
Funding and support
Thank you to the following organisations for their support:
- National Foundation for Medical Research & Innovation (NFMRI)
- Alzheimer’s Drug Discovery Foundation (ADDF) Diagnostics Accelerator (RDAPB-201809).
- CERA Innovation Fund.
- Dr Steven Frisken (Philanthropic donation. Eyes and the sky)
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