CERA

About

Dr Thomas Edwards

Principal Investigator, Head of Retinal Gene Therapy Research

Dr Thomas Edwards leads international clinical trials of gene therapy for inherited retinal diseases and is developing several new treatments in his laboratory.

Dr Thomas Edwards

Principal Investigator, Head of Retinal Gene Therapy Research

MBBS, PhD, FRANZCO

Dr Thomas Edwards is a vitreoretinal surgeon and leads CERA’s Retinal Gene Therapy Research team. He is one of a handful of surgeons in Australia who has expertise in retinal gene therapy surgery and also has an interest in technical innovations such as robotics.

He undertook a PhD at the University of Cambridge in medical genetics before completing his ophthalmology training at The Royal Victorian Eye and Ear Hospital in Melbourne.

In 2014, he was awarded a Nuffield Medical Fellowship by the Australian Academy of Sciences to undertake specialist vitreoretinal surgical training and research under Professor Robert MacLaren at the University of Oxford. Here, he worked on the world-first clinical trial of gene therapy to treat choroideremia, a type of inherited retinal degeneration.

Dr Edwards’ research covers both clinical and preclinical programs. In collaboration with Professor Lauren Ayton AM, he leads the VENTURE inherited retinal disease (IRD) registry.  He leads several international gene therapy and other pharmaceutical trials through our sister company, Cerulea Clinical Trials. Additionally, his team are developing new gene therapies for IRDs in his laboratory.

Dr Edwards’ research has been supported by funding from organisations such as Australian Vision Research (AVR), and he is a prior recipient of the prestigious University of Melbourne Annemarie Manciewicz-Zeldin Fellowship.

Key research questions
  • Are emerging gene therapies safe and effective for people with inherited retinal diseases?
  • What are the most appropriate surgical methods to deliver gene therapy to people with inherited retinal diseases?
  • Can we develop our own locally developed treatments in Melbourne?

Selected publications

My team

Funding and support

Selected publications

Xue K, Jolly JK, Barnard AR, Rudenko A, Salvetti AP, Patrício MI, Edwards TL, Groppe M, Orlans HO, Tolmachova T, Black GC, Webster AR, Lotery AJ, Holder GE, Downes SM, Seabra MC, MacLaren RE. Beneficial effects on vision in patients undergoing retinal gene therapy for choroideremia. Nature Medicine. 2018 Oct;24(10):1507-1512. DOI: 10.1038/s41591-018-0185-5

Edwards TL, Xue K, Meenink HCM, et al. First-in-human study of the safety and viability of intraocular robotic surgery. Nature Biomedical Engineering, 2018;18:2, 649-656. https://doi.org/10.1038/s41551-018-0248-4

Edwards TL, Cottriall CL, Xue K, et al. Assessment of the Electronic Retinal Implant Alpha AMS in Restoring Vision to Blind Patients with End-Stage Retinitis Pigmentosa. Ophthalmology 2017;125:432–443. DOI: 10.1016/j.ophtha.2017.09.019

Edwards TL, Jolly JK, Groppe M, et al. Visual Acuity after Retinal Gene Therapy for Choroideremia. N Engl J Med. 2016;374:1996–1998. DOI: 10.1056/NEJMc1509501

Edwards TL, Groppe M, Jolly JK, Downes, SM, MacLaren, RE, Correlation of retinal structure and function in choroideremia carriers, Ophthalmology, 2015 Jun;122(6):1274-6. DOI: 10.1016/j.ophtha.2014.12.036

See more publications

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