About
Associate Professor Guei-Sheung (Rick) Liu
Principal Investigator, Head of Genetic Engineering Research
Associate Professor Guei-Sheung (Rick) Liu investigates ways advanced gene technology can improve the treatment of eye diseases that cause blindness.
Associate Professor Guei-Sheung (Rick) Liu
Principal Investigator, Head of Genetic Engineering Research
BMedSci, PhD
Associate Professor Guei-Sheung (Rick) Liu is a Principal Investigator and leads the genetic engineering research unit at the Centre for Eye Research Australia.
He received his PhD in biochemistry from Kaohsiung Medical University and was a postdoc at the O’Brien Institute and Centre for Eye Research Australia and University of Melbourne.
A/Prof Liu has significant expertise in gene technologies with over 80 publications and continuous funding from the NHMRC and other agencies since 2012.
Over the last 5 years, his research has specifically delved into the fields of gene editing and regulable gene delivery, with a focus to refine these applications to clear the current hurdles impeding clinical translation for ocular gene therapy.
A/Prof Liu serves on the editorial board of PLoS One, Journal of Gene Medicine and Frontiers in Pharmacology. He also holds the appointment as an adjunct Investigator at the Taipei Medical University (Bioengineering) and Senior Fellow (Ophthalmology) at the University of Melbourne.
Key research questions
- Can emerging gene technology such as gene editing be used to treat eye diseases?
- Can we customise gene therapy to achieve safe and effective treatments to prevent vision loss?
- Can nanocarrier improve the efficacy of the drug and gene delivery in the eye?
Current projects
Selected publications
My team
Key collaborators
Funding and support
Current projects
Switchable gene therapy for controlled intervention in neovascular blindness
This project aims to develop an eye drop based-tunable gene therapy for long-term and tailored managing neovascular eye diseases.
CRISPR gene editing to treat eye diseases
This project aims to use the latest gene editing technologies to develop novel gene therapies for neovascular eye diseases and inherited retinal diseases.
Nanoparticle-based technologies for ocular gene therapy
The collaborative project aims to use nanoparticle technology to improve the effectiveness and specificity of mRNA-based gene therapy in the treatment of eye diseases.
Selected publications
Chen J, Lin FL, Leung JYK, Tu L, Wang JH, Chuang YF, Li F, Shen HH, Dusting GJ, Wong VHY, Lisowski L, Hewitt AW, Bui BV, Zhong J, Liu GS. A Drug-tunable Flt23k Gene Therapy for Controlled Intervention in Retinal Neovascularization. Angiogenesis, 2021;24(1):97-110.
doi:10.1007/s10456-020-09745-7
Lin FL, Wang PY, Chuang YF, Wang JH, Wong VHY, Bui BV, Liu GS. Gene Therapy Intervention in Neovascular Eye Disease: A Recent Update. Mol Ther 2020;28(10):2120-2138.
doi:10.1016/j.ymthe.2020.06.029
Lee JH, Wang JH, Chen J, Li F, Edwards TL, Hewitt AW, Liu GS. Gene Therapy for Visual Loss: Opportunities and Concerns. Prog Retin Eye Res 2019;68:31-53.
doi:10.1016/j.preteyeres.2018.08.003
Tu L, Wang JH, Barathi VA, Prea SM, He Z, Lee JH, Bender J, King AE, Logan GJ, Alexander IE, Bee YS, Tai MH, Dusting GJ, Bui BV, Zhong J, Liu GS. AAV-mediated Gene Delivery of the Calreticulin Anti-angiogenic Domain Inhibits Ocular Neovascularization. Angiogenesis 2018;21(1):95-109.
Hung SS, Chrysostomou V, Li F, Lim JK, Wang JH, Powell JE, Tu L, Daniszewski M, Lo C, Wong RC, Crowston JG, Pébay A, King AE, Bui BV, Liu GS, Hewitt AW. AAV-Mediated CRISPR/Cas Gene Editing of Retinal Cells In Vivo. Invest Ophthalmol Vis Sci 2016;57(7):3470-3476.
My team
- Layal El Wazan – Research Assistant
- Satheesh Kumar – PhD Student
Key collaborators
Australia
- Prof Alex Hewitt – CERA
- A/Prof Chi Luu – CERA
- Dr Tom Edwards – CERA
- A/Prof Bang Bui – University of Melbourne
- Prof Kathryn Burdon – University of Tasmania
- Prof Joanne Dickinson – University of Tasmania
International
- Prof Ching-Li Tseng – Taipei Medical University
Funding and support
Thank you to the following organisations for their support:
- National Health and Medical Research Council
- Ophthalmic Research Institute of Australia
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